منابع مشابه
Immunological memory in innate immunity.
‘trained immunity’. Trained immunity provides protection against reinfection in a T-/B-cell-independent manner, with nonspecific potentiation of inflammatory reactions and antimicrobial mechanisms playing a central role in these effects [4] . The current issue of the Journal of Innate Immunity presents a series of studies that shed additional light on important aspects of the adaptive propertie...
متن کاملTranslating Innate Immunity into Immunological Memory: Implications for Vaccine Development
Vaccination is the most effective means of preventing infectious diseases. Despite the success of many vaccines, there is presently little knowledge of the immunological mechanisms that mediate their efficacy. Such information will be critical in the design of future vaccines against old and new infectious diseases. Recent advances in immunology are beginning to provide an intellectual framewor...
متن کاملImmunological memory within the innate immune system.
Immune memory has traditionally been the domain of the adaptive immune system, present only in antigen-specific T and B cells. The purpose of this review is to summarize the evidence for immunological memory in lower organisms (which are not thought to possess adaptive immunity) and within specific cell subsets of the innate immune system. A special focus will be given to recent findings in bot...
متن کاملInnate immunity
From the discovery of antibodies in the late nineteenth century until very recently, the focus of most research in immunology has been the so-called adaptive immune response. Adaptive immune responses are highly specific for a given microorganism and it is the T and B lymphocytes of the adaptive immune response, and the antibodies produced by the B lymphocytes, that are responsible for lasting ...
متن کاملMitochondria in innate immunity.
Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 a...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2014
ISSN: 1662-8128,1662-811X
DOI: 10.1159/000357283